![]() 11 Since that time, and especially over the last 5 years, an increasing number of novel DMTs have been approved for the treatment of MS. Twenty-five years ago, the first disease-modifying treatment (DMT), interferon beta-1b, was approved by the US FDA for the treatment of MS. 2,4 MS is associated with a heterogeneous array of signs and symptoms because of involvement of the motor, sensory, visual, and autonomic systems. ![]() ![]() 6-8 MS affects roughly 400,000 people in the United States and 2.5 million people worldwide. 1-5 Although descriptions date back as far as the Middle Ages, MS was first recognized as a distinct disease in 1868 when Jean-Martin Charcot, professor of Neurology at the University of Paris, referred to the condition as sclérose en plaques. Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS) characterized by inflammation, demyelination, and axonal degeneration.
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